Initial development of a multistage cancer model based on Syrian hamster embryo (SHE) cell transformation studies
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To better incorporate biologic information into quantitative cancer modeling, the two-stage MVK (Moolgavkar-Venzon-Knudson) model has been modified for use with SHE cell neoplastic progression. Conceptually, five phenotypic stages are included in this model: normal cells can either become senescent or mutate into immortal cells followed by anchorage-independent growth and tumorigenic stages. Cells in each stage have distinct division, death and mutation rates, and mutation is assumed to occur during cell division. Model development and related experiments were focused on studying the abilities ...
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Criteria for evaluating model deficiency for groundwater models and the effects of eliminating deficient models on multi-model analysis using AICC, KIC, AIC, and BIC Contributor:Schenk, Judith A.;
Date Submitted:2017Multi-model analysis (MMA) considers multiple model interpretations of a system. MMA provides a more realistic assessment of uncertainty associated with model predictions because both uncertainty of individual models and ...
Binder 1. Basin Model. Model Development/Black Canyon Flows/ Requests for Modeling/Water Rights Decrees Contributor:WBLA, Inc.; Colorado Water Resources and Power Development Authority; HDR Engineering, Inc.
Date:1987-1989Supporting materials assembled for the Upper Gunnison-Uncompaghre Basin Study. Tabbed topics in Binder 1: Basin Study include model development, Black Canyon flows, requests for modeling, and water rights decrees.
Improving U.S. national water modeling : an intercomparison of two high-resolution, continental scale models, ParFlow-CONUS and the National Water Model v1.2 configuration of WRF-Hydro Contributor:Tijerina, Danielle T.;
Date Submitted:2018Development of integrated hydrology modeling systems, where subsurface, land-surface, and energy budget processes are represented, is an increasing trend. In hydrologic science, there is a need for more intricate models ...