Studies toward the total synthesis of Fusarin C
| dc.contributor.author | Esslinger, Christopher Sean, author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.date.accessioned | 2022-11-28T17:44:47Z | |
| dc.date.available | 2022-11-28T17:44:47Z | |
| dc.date.issued | 1996 | |
| dc.description.abstract | The development of the synthesis of the heterocyclic proposed pharmacaphore of the natural mutagenic fungal metabolite fusarin C is discussed with the result of a short and elegant synthesis for this portion of the molecule. The structural integrity of this compound was studied giving rise to a method of diastereomeric preference. Studies to further the synthesis of the natural product are discussed which result in successful alkylation of the heterocycle. The alkylation procedure then produced two new non-natural products which when tested for mutagenic activity along with the heterocycle, may provide information as to the function of the penta-ene side chain of fusarin C in regard to mutagenic activity. | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier.uri | https://hdl.handle.net/10217/235830 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation | Catalog record number (MMS ID): 991019546229703361 | |
| dc.relation | QK625.F8E77 1996 | |
| dc.relation.ispartof | 1980-1999 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | Fusarium | |
| dc.subject | Pathogenic fungi | |
| dc.subject | Organic compounds -- Synthesis | |
| dc.title | Studies toward the total synthesis of Fusarin C | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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