Design and synthesis of analogs of the peptidylnucleoside antibiotics: the mureidomycins
| dc.contributor.author | Bender, David Michael, author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.date.accessioned | 2022-11-28T17:44:50Z | |
| dc.date.available | 2022-11-28T17:44:50Z | |
| dc.date.issued | 1998 | |
| dc.description.abstract | The recent emergence of strains of bacteria which are resistant to many commercially available antibiotics requires a continual search for new drugs to combat infection. A new family of antibiotics, the mureidomycins, has recently been reported. These compounds have been shown exhibit activity against Pseudomonas aeruginosa through inhibition of phospho-N-acetylmuramyl translocase, an enzyme involved in the lipid cycle of peptidolycan biosynthesis. Progress toward the total synthesis of this series of natural products is described. Specifically, methodology for the production of 4',5'-unsaturated enamine nucleosides has been investigated. In addition, two unnatural amino acids, (S)-m-tyrosine and 2-amino-3-N-methylaminobuyric acid, have been synthesized in optically pure form. Molecular modeling was used to predict structural analogs of the mureidomycin antibiotics. These compounds are simple peptidylnucleosides and are derived from coupling of small amino acid subunits to an aminonucleoside core. The synthesis of these analogs is described, including a novel route to 3',5' -dideoxy-5'aminouridine. | |
| dc.format.medium | masters theses | |
| dc.identifier.uri | https://hdl.handle.net/10217/235836 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation | Catalog record number (MMS ID): 991004477269703361 | |
| dc.relation | RS431.P37B45 1998 | |
| dc.relation.ispartof | 1980-1999 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | Peptide antibiotics | |
| dc.title | Design and synthesis of analogs of the peptidylnucleoside antibiotics: the mureidomycins | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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