Next generation antibiotics: progress toward the synthesis of an enzyme-activated nitric oxide-releasing fluorescent prodrug
| dc.contributor.author | Hibbard, Hailey A. J., author | |
| dc.contributor.author | Reynolds, Melissa M., author | |
| dc.date.accessioned | 2017-11-13T14:18:30Z | |
| dc.date.available | 2017-11-13T14:18:30Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Bacterial resistance to antibiotics is spreading at an alarming rate, and without the development of new antibiotics, common infections will become deadly. The goal of this project is to synthesize an enzyme-activated antibiotic prodrug that detects and kills bacteria. The antibiotic will incorporate nitric oxide, a known antibacterial agent, and a fluorescent compound to visualize bacterial presence. A synthesis procedure was developed to synthesize a fluorescent compound attached to a small signaling compound. A nitric oxide donor will be added in the future. In the presence of bacteria, the antibiotic prodrug is designed to simultaneously fluoresce and release nitric oxide. | en_US |
| dc.format.medium | born digital | |
| dc.format.medium | Student works | |
| dc.format.medium | posters | |
| dc.identifier.uri | https://hdl.handle.net/10217/184831 | |
| dc.language | English | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Colorado State University. Libraries | en_US |
| dc.relation.ispartof | 2017 Projects | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.title | Next generation antibiotics: progress toward the synthesis of an enzyme-activated nitric oxide-releasing fluorescent prodrug | en_US |
| dc.title.alternative | 134 - Hailey Hibbard | en_US |
| dc.title.alternative | Synthesis of an enzyme-activated nitric oxide-releasing antibacterial prodrug | en_US |
| dc.type | Text | |
| dc.type | Image | |
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