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Synthesis of a photo-activated analog of the antitumor antibiotic FR 900482

dc.contributor.authorRollins, Samuel Burke, author
dc.contributor.authorWilliams, Robert M., advisor
dc.date.accessioned2022-11-28T17:44:48Z
dc.date.available2022-11-28T17:44:48Z
dc.date.issued1997
dc.description.abstractA novel synthetic route to the benzazocine framework of the antitumor antibiotic FR 900482 is presented. The synthesis of the benzazocine ring is characterized by a convergent asymmetric strategy. Although the benzazocine ring was not elaborated into the bicyclic skeleton of the natural product, synthesis of a hitherto unknown class of latent mitosenes was accomplished. Acylation of the benzazocine nitrogen with a photo cleavable protecting group allowed for the formation of the highly reactive mitosene under non-reductive conditions.
dc.format.mediumdoctoral dissertations
dc.identifier.urihttps://hdl.handle.net/10217/235832
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relationCatalog record number (MMS ID): 991008181819703361
dc.relationRC271.A65R65 1997
dc.relation.ispartof1980-1999
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectAntineoplastic antibiotics
dc.subjectOrganic compounds -- Synthesis
dc.titleSynthesis of a photo-activated analog of the antitumor antibiotic FR 900482
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineChemistry
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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