Synthesis of a photo-activated analog of the antitumor antibiotic FR 900482
| dc.contributor.author | Rollins, Samuel Burke, author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.date.accessioned | 2022-11-28T17:44:48Z | |
| dc.date.available | 2022-11-28T17:44:48Z | |
| dc.date.issued | 1997 | |
| dc.description.abstract | A novel synthetic route to the benzazocine framework of the antitumor antibiotic FR 900482 is presented. The synthesis of the benzazocine ring is characterized by a convergent asymmetric strategy. Although the benzazocine ring was not elaborated into the bicyclic skeleton of the natural product, synthesis of a hitherto unknown class of latent mitosenes was accomplished. Acylation of the benzazocine nitrogen with a photo cleavable protecting group allowed for the formation of the highly reactive mitosene under non-reductive conditions. | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier.uri | https://hdl.handle.net/10217/235832 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation | Catalog record number (MMS ID): 991008181819703361 | |
| dc.relation | RC271.A65R65 1997 | |
| dc.relation.ispartof | 1980-1999 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject.lcsh | Antineoplastic antibiotics | |
| dc.subject.lcsh | Organic compounds -- Synthesis | |
| dc.title | Synthesis of a photo-activated analog of the antitumor antibiotic FR 900482 | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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