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Feed zone micromixing and its effect on continuous cultures of Saccharomyces cerevisiae

dc.contributor.authorMondani, Paul, author
dc.contributor.authorLoftis, J. C., advisor
dc.date.accessioned2023-07-24T18:55:43Z
dc.date.available2023-07-24T18:55:43Z
dc.date.issued1995
dc.descriptionCovers not scanned.
dc.descriptionPrint version deaccessioned 2023.
dc.description.abstractInadequate mixing is known to be a common problem in the scale-up of bioprocesses, often leading to decreases in yield and productivity. To investigate the role of nutrient dispersion in continuous cultures, growth medium was fed into a laminar flow section of a loop that recirculates broth from a laboratory scale bioreactor. The intensity of micromixing at the feed site could be controlled by varying the axial distance a static mixer was placed upstream of the site. The intensity of the turbulent wake shed by the mixer was quantified by laser Doppler velocimetry and the Bourne dye reaction. By decreasing the size of the smallest turbulent eddy in the feed zone, less of the population is exposed to regions of either inadequate or excessive substrate concentrations. Yield vs. dilution rate curves were obtained through various mixing and feeding strategies. Reduced mixing was shown to delay the onset of the Crabtree effect and therefore improve the bioreactor's productivity.
dc.format.mediummasters theses
dc.identifier.urihttps://hdl.handle.net/10217/236767
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relationCatalog record number (MMS ID): 991024448839703361
dc.relationTP248.25.B55M65 1995
dc.relation.ispartof1980-1999
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectSaccharomyces cerevisiae
dc.subjectBioreactors
dc.subjectFermentation
dc.titleFeed zone micromixing and its effect on continuous cultures of Saccharomyces cerevisiae
dc.typeText
dc.typeStillImage
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineChemical and Bioresource Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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