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Phototunable block copolymer hydrogels

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dc.contributor.authorHuq, Nabila A., author
dc.contributor.authorBailey, Travis S., advisor
dc.contributor.authorKipper, Matthew J., committee member
dc.contributor.authorReynolds, Melissa M., committee member
dc.contributor.authorSnow, Christopher D., committee member
dc.date.accessioned2018-01-17T16:46:05Z
dc.date.available2019-01-12T16:46:14Z
dc.date.issued2017
dc.description.abstractThermoplastic elastomer (TPE) hydrogel networks, based on swelling of nanostructured blends of amphiphilic, sphere-forming AB diblock and ABA triblock copolymers, provide direct access to thermally processable plastics that exhibit exceptional elastic recovery and fatigue resistance even after hydration. In such two-component systems, the ratio of ABA to AB block copolymer (BCP) is used to control the resultant swelling ratio, system modulus, and overall mechanical response. This dissertation focuses on developing material strategies through which adjustment of such AB/ABA ratios, and thus the resultant properties, can be accomplished using light. The chapters within capture the manipulation of a photoreactive AB diblock copolymer micelle-like spheres to controllably generate ABA triblock copolymer and the network nanostructure in situ, both in the melt state and after dispersal in solution. This was accomplished using efficient photoinduced [4 + 4]cycloaddition (λ = 365 nm) between terminal anthracene units on a ω-anthracenylpolystyrene-b-poly(ethylene oxide) diblock copolymer precursor to produce the desired amount of polystyrene-b-poly(ethylene oxide)-b-polystyrene triblock copolymer. This direct, UV-mediated handle on tethering between adjacent micelles in the BCP matrix was found to be capable of controllably manipulating hydrogel material properties using (1) duration of irradiation, (2) hydration level and consequent micelle spacing upon exposure, and (3) photopatterning strategies to spatially direct swelling and mechanics. This level of control yielded an array of hydrogels, ranging from those irradiated in the dry melt to produce high-modulus, elastic materials suited for fibrocartilage repair and replacement, to moldable or injectable precursor solutions irradiated into soft, conformally shaped TPE hydrogels ideal for use in high contact applications such as wound healing. The development and scope of this versatile new photoactive BCP system is enclosed.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierHuq_colostate_0053A_14567.pdf
dc.identifier.urihttps://hdl.handle.net/10217/185744
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectblock copolymer
dc.subjectmicelle
dc.subjectthermoplastic elastomer
dc.subjecthydrogel
dc.subjectanthracene
dc.subjectphototunable
dc.titlePhototunable block copolymer hydrogels
dc.typeText
dcterms.embargo.expires2019-01-12
dcterms.embargo.terms2019-01-12
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineChemical and Biological Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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