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Titania nanotube arrays: interfaces for implantable devices

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dc.contributor.authorSmith, Barbara Symie, author
dc.contributor.authorPopat, Ketul, advisor
dc.contributor.authorGonzalez-Juarrero, Mercedes, committee member
dc.contributor.authorPrasad, Ashok, committee member
dc.contributor.authorDasi, Lakshmi Prasad, committee member
dc.contributor.authorDow, Steven, committee member
dc.date.accessioned2007-01-03T08:10:10Z
dc.date.available2007-01-03T08:10:10Z
dc.date.issued2012
dc.description.abstractFor the 8-10% of Americans (20-25 million people) that have implanted biomedical devices, biomaterial failure and the need for revision surgery are critical concerns. The major causes for failure in implantable biomedical devices promoting a need for re- implantation and revision surgery include thrombosis, post-operative infection, immune driven fibrosis and biomechanical failure. The successful integration of long-term implantable devices is highly dependent on the early events of tissue/biomaterial interaction, promoting either implant rejection or a wound healing response (extracellular matrix production and vasculature). Favorable interactions between the implant surface and the respective tissue are critical for the long-term success of any implantable device. Recent studies have shown that material surfaces which mimic the natural physiological hierarchy of in vivo tissue may provide a possible solution for enhancing biomaterial integration, thus preventing infection and biomaterial rejection. Titania nanotube arrays, fabricated using a simple anodization technique, provide a template capable of promoting altered cellular functionality at a hierarchy similar to that of natural tissue. This work focuses on the fabrication of immobilized, vertically oriented and highly uniform titania nanotube arrays to determine how this specific nano-architecture affects skin cell functionality, hemocompatibility, thrombogenicity and the immune response. The results in this work identify enhanced dermal matrix production, altered hemocompatibility, reduced thrombogenicity and a deterred immune response on titania nanotube arrays. This evidences promising implications with respect to the use of titania nanotube arrays as beneficial interfaces for the successful implantation of biomedical devices.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierSmith_colostate_0053A_10938.pdf
dc.identifierETDF2012400275BIOM
dc.identifier.urihttp://hdl.handle.net/10217/67643
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjecthemocompatibility
dc.subjecttitania nanotube arrays
dc.subjectnanotechnology
dc.subjectimmune response
dc.subjectimplantable biomedical devices
dc.subjectbiomaterials
dc.titleTitania nanotube arrays: interfaces for implantable devices
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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