Software for the use of protein fragment recombination and regression in protein structure determination and design
| dc.contributor.author | Lunt, Mark, author | |
| dc.contributor.author | Snow, Christopher, advisor | |
| dc.contributor.author | Fisk, Nick, committee member | |
| dc.contributor.author | Ben-Hur, Asa, committee member | |
| dc.date.accessioned | 2015-08-27T03:57:27Z | |
| dc.date.available | 2017-06-03T03:57:27Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Recombination of protein structural fragments, in combination with regression-based scoring schemes, provides an alternative to existing iterative strategies for conducting a search over protein conformations. We developed software to define astronomically large combinatorial protein conformation search spaces, and to efficiently search those spaces. We demonstrate that such methods may be applicable to the structure prediction of cytochrome P450 chimeras. More generally, we demonstrate that such methods can be used to produce high-quality protein structural models given only low-resolution X-ray diffraction data. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier.uri | http://hdl.handle.net/10217/167036 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | recombination | |
| dc.subject | protein | |
| dc.subject | regression | |
| dc.title | Software for the use of protein fragment recombination and regression in protein structure determination and design | |
| dc.type | Text | |
| dcterms.embargo.expires | 2017-06-03 | |
| dcterms.embargo.terms | 2017-06-03 | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemical and Biological Engineering | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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