Repository logo
 

Telomere length as a biomarker of exposure to indoor woodstove smoke in rural Honduras: a feasibility field study

Simple item page
dc.contributor.authorAltina, Noelia, author
dc.contributor.authorDeLuca, Jennifer, advisor
dc.contributor.authorBailey, Susan, advisor
dc.contributor.authorRoss, Eric, committee member
dc.contributor.authorClark, Maggie, committee member
dc.date.accessioned2017-09-14T16:06:58Z
dc.date.available2018-09-12T16:04:38Z
dc.date.issued2017
dc.description.abstractTelomeres, the natural ends of linear chromosomes, are important for maintaining genome stability. Telomere length is an inherited trait influenced by a host of lifestyle and environmental factors, which have been shown to accelerate the rate of telomere shortening, and thus of aging. Indoor air pollution is one of the environmental factors known to influence the length of telomeres. It has been reported that people exposed to this kind of contamination, have an increased risk for pulmonary diseases, cardiovascular diseases and cancer. The accumulation of evidence correlating telomere length with different diseases and chronological age supports the use of short telomere frequency as an informative biomarker of general health status and aging. Epidemiological studies suggest that increased frequencies of nuclear aberrations (micronuclei, buds) are also correlated with exposure to air pollution.
dc.description.abstractHere, we confirm the feasibility of conducting field studies to evaluate telomere length in populations exposed to indoor air pollution in rural Honduras, and begin to address the question of whether telomere length can be used as an informative biomarker of exposure to indoor woodstove smoke. Buccal mucosa basal (stem-like) cells were collected from 100 exposed individuals in the field (prior to intervention); samples were shipped to US (CSU) for assessment of average telomere length (TL) and frequency of short telomeres. Results were correlated with age for all participants, and with total number of nuclear aberrations in a subset (20 individuals). Initial analyses suggest that frequencies of short telomeres, rather than average telomere length, correlate with total number of nuclear aberrations in those assumed to be the most exposed individuals. These preliminary findings require correlation with actual particulate matter exposures, as well as confirmation in a larger cohort (studies on-going).
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierAltina_colostate_0053N_14423.pdf
dc.identifier.urihttps://hdl.handle.net/10217/184046
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectinterphase Telo-FISH
dc.subjectstem-like cells
dc.subjectbiomarker
dc.subjecttotal nuclear aberrations
dc.subjectshort telomere percentage
dc.titleTelomere length as a biomarker of exposure to indoor woodstove smoke in rural Honduras: a feasibility field study
dc.typeText
dcterms.embargo.expires2018-09-12
dcterms.embargo.terms2018-09-12
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBiochemistry and Molecular Biology
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Altina_colostate_0053N_14423.pdf
Size:
1.33 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

2000-2019
Theses and Dissertations