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The development of hyaluronan enhanced expanded polytetrafluoroethylene and linear low density polyethylene for blood contacting applications

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dc.contributor.authorBui, Hieu T., author
dc.contributor.authorJames, Susan, advisor
dc.contributor.authorReynolds, Melissa, committee member
dc.contributor.authorPopat, Ketul, committee member
dc.contributor.authorOlver, Christine, committee member
dc.date.accessioned2019-06-14T17:06:51Z
dc.date.available2019-06-14T17:06:51Z
dc.date.issued2019
dc.description.abstractCardiovascular disease is the number one cause of death in high income, industrialized countries. Designing cardiovascular implants from synthetic polymers is a cost-effective solution to the growing demand for medical treatments such as heart valve replacements and cardiovascular bypass procedures. Synthetic polymers are often known for their tunability, durability, and low production cost. Unfortunately, these materials are also prone to induce thrombosis. Therefore, improving the blood compatibility of these polymers is still a major challenge in the biomedical field. This dissertation discusses the alteration of two synthetic polymers, linear low density polyethylene (LLDPE) and expanded polytetrafluoroethylene (ePTFE), using hyaluronan (HA) to improve their blood compatibility. HA, a naturally occurring polysaccharide in the human body, is known for its wound healing and anticoagulant properties. In this work, two unique methods were developed for HA enhancement of ePTFE (HA-ePTFE) and LLDPE (HA-LLDPE). This was a process driven research that aimed at designing HA-ePTFE and HA-LLDPE by analyzing the effect of different treatment parameters on the properties of the resultant materials. In the case of ePTFE, it was demonstrated that HA can be incorporated into vascular ePTFE grafts by exploiting the micro pores of the polymer and adjusting the spraying treatment. In the HA-LLDPE fabrication process, its parameters were varied to assess their effects on the interpenetrating polymer network (IPN) formation. Surface characterization such as water contact angle goniometry, infrared spectroscopy, and toluidine blue O (TBO) staining prove that HA treatment successfully changed the surface chemistry and increased the hydrophilicity of ePTFE and LLDPE. Thermal analysis and gas chromatography-mass spectrometry were used to quantify the effects of different treatment conditions on material properties. Tensile properties such as elastic modulus, tensile strength, yield stress and ultimate strain are unchanged by HA enhancement for both polymers. The biological results reveal that HA-ePTFE and HA-LLDPE are not cytotoxic and result in less blood clotting and platelet activation than ePTFE and LLDPE.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierBui_colostate_0053A_15450.pdf
dc.identifier.urihttps://hdl.handle.net/10217/195402
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectcardiovascular
dc.subjecthyaluronic acid
dc.subjectvascular graft
dc.subjectheart valve
dc.subjectbiomaterials
dc.subjectpolymer
dc.titleThe development of hyaluronan enhanced expanded polytetrafluoroethylene and linear low density polyethylene for blood contacting applications
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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