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Socioeconomic inequality, amygdala and ventral striatal connectivity, and affective outcomes in children and adolescents

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dc.contributor.authorStrack, Jordan, author
dc.contributor.authorMerz, Emily, advisor
dc.contributor.authorThomas, Michael, committee member
dc.contributor.authorSeger, Carol, committee member
dc.contributor.authorLucas-Thompson, Rachel, committee member
dc.date.accessioned2023-06-01T17:27:22Z
dc.date.available2023-06-01T17:27:22Z
dc.date.issued2023
dc.description.abstractSocioeconomic disadvantage has been significantly associated with an increased risk for internalizing problems in children and adolescents. The neural mechanisms underlying these associations, however, are not well understood. Differences in connectivity of the amygdala and ventral striatum with the prefrontal cortex (PFC) may play an important role in these mechanisms. The goals of this study were to examine (1) the associations among socioeconomic factors, amygdala and ventral striatal resting-state functional connectivity (rsFC), and emotional outcomes in children and adolescents, (2) sex differences in associations between socioeconomic factors and amygdala and ventral striatal rsFC, and (3) interactions between socioeconomic factors and familial/genetic risk for anxiety/depression in predicting amygdala and ventral striatal rsFC. Participants were typically-developing 3- to 20-year-olds (50% male, N = 590) from the Pediatric Imaging, Neurocognition, and Genetics (PING) study (Jernigan et al., 2016). Resting-state fMRI, socioeconomic (family income, parental education), and self-reported positive and negative affect data were collected. Measures of familial and genetic risk for anxiety/depression were family history of anxiety/depression and genome-wide polygenic risk scores for major depressive disorder (PRS-MDD), respectively. Whole-brain, seed-based functional connectivity analyses were conducted with the ventral striatum and the amygdala as seeds. Findings indicated significant interactions between socioeconomic factors and PRS-MDD for amygdala rsFC with the frontopolar cortex. Positive and negative affect were associated with amygdala and ventral striatum rsFC with various brain regions. Associations between socioeconomic factors and amygdala and ventral striatal rsFC and sex differences were not significant. These findings can be applied to informing the design of more effective prevention and intervention strategies to facilitate healthy emotional development.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierStrack_colostate_0053N_17711.pdf
dc.identifier.urihttps://hdl.handle.net/10217/236613
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectamygdala
dc.subjectsocioeconomic inequality
dc.subjectaffect
dc.subjectventral striatum
dc.subjectfunctional connectivity
dc.titleSocioeconomic inequality, amygdala and ventral striatal connectivity, and affective outcomes in children and adolescents
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplinePsychology
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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