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    Clustering of non-conducting Kv2.1 channels induces endoplasmic reticulum/plasma membrane junctions and forms cell-surface trafficking hubs

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    http://hdl.handle.net/10217/88429
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    Abstract
    The voltage-gated K+ channel, Kv2.1, is expressed widely in the mammalian CNS, where it carries the majority of the delayed-rectifier current. The Kv2.1 current facilitates high-frequency action potential firing by promoting the repolarization of the membrane potential and subsequent recovery of voltage-gated Na+ channels from inactivation. Furthermore, Kv2.1 displays a unique cell-surface localization to dense, micron-sized clusters which are sensitive to neuronal insults such as glutamate excitotoxicity. The following dissertation presents original research extending our knowledge of the ...
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    Author(s)
    Fox, Philip Douglas

    Advisor(s)
    Tamkun, Michael M.

    Date Issued
    2014
    Format
    born digital; doctoral dissertations
    Collections
    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Graduate Degree Program in Cell & Molecular Biology

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