Part one: The formal total synthesis of dehydrogliotoxin and the first synthesis of an epidiselenodiketopiperazine and Part two: Towards the total synthesis of the tetrapetalones
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), affects approximately one third of the global population and is associated with nearly two million deaths annually. Although there are known cures for TB, current treatment plans suffer due to length, usually taking 6-9 months to complete. Additionally, developing countries lack the infrastructure and resources necessary to both efficiently diagnose and treat patients. Of particular concern are an increasing number of strains of TB that are becoming resistant to the current drug regimens, which has been a result of patients beginning, ...
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