dc.contributor.advisor | Popat, Ketul |
dc.contributor.author | Smith, Barbara Symie |
dc.contributor.committeemember | Gonzalez-Juarrero, Mercedes |
dc.contributor.committeemember | Prasad, Ashok |
dc.contributor.committeemember | Dasi, Lakshmi Prasad |
dc.contributor.committeemember | Dow, Steven |
dc.date.accessioned | 2007-01-03T08:10:10Z |
dc.date.available | 2007-01-03T08:10:10Z |
dc.date.issued | 2012 |
dc.description | 2012 Spring. |
dc.description | Includes bibliographical references. |
dc.description.abstract | For the 8-10% of Americans (20-25 million people) that have implanted biomedical devices, biomaterial failure and the need for revision surgery are critical concerns. The major causes for failure in implantable biomedical devices promoting a need for re- implantation and revision surgery include thrombosis, post-operative infection, immune driven fibrosis and biomechanical failure. The successful integration of long-term implantable devices is highly dependent on the early events of tissue/biomaterial interaction, promoting either implant rejection or a wound healing response (extracellular matrix production and vasculature). Favorable interactions between the implant surface and the respective tissue are critical for the long-term success of any implantable device. Recent studies have shown that material surfaces which mimic the natural physiological hierarchy of in vivo tissue may provide a possible solution for enhancing biomaterial integration, thus preventing infection and biomaterial rejection. Titania nanotube arrays, fabricated using a simple anodization technique, provide a template capable of promoting altered cellular functionality at a hierarchy similar to that of natural tissue. This work focuses on the fabrication of immobilized, vertically oriented and highly uniform titania nanotube arrays to determine how this specific nano-architecture affects skin cell functionality, hemocompatibility, thrombogenicity and the immune response. The results in this work identify enhanced dermal matrix production, altered hemocompatibility, reduced thrombogenicity and a deterred immune response on titania nanotube arrays. This evidences promising implications with respect to the use of titania nanotube arrays as beneficial interfaces for the successful implantation of biomedical devices. |
dc.format.medium | born digital |
dc.format.medium | doctoral dissertations |
dc.identifier | Smith_colostate_0053A_10938.pdf |
dc.identifier | ETDF2012400275BIOM |
dc.identifier.uri | http://hdl.handle.net/10217/67643 |
dc.language | English |
dc.publisher | Colorado State University. Libraries |
dc.relation.ispartof | 2000-2019 - CSU Theses and Dissertations |
dc.rights | Copyright of the original work is retained by the author. |
dc.subject | hemocompatibility |
dc.subject | titania nanotube arrays |
dc.subject | nanotechnology |
dc.subject | immune response |
dc.subject | implantable biomedical devices |
dc.subject | biomaterials |
dc.title | Titania nanotube arrays: interfaces for implantable devices |
dc.type | Text |
dcterms.rights.dpla | The copyright and related rights status of this item has not been evaluated (https://rightsstatements.org/vocab/CNE/1.0/). Please refer to the organization that has made the Item available for more information. |
thesis.degree.discipline | Biomedical Engineering |
thesis.degree.grantor | Colorado State University |
thesis.degree.level | Doctoral |
thesis.degree.name | Doctor of Philosophy (Ph.D.) |