Effect of dominant negative MKK expression on pH-induced increases in PEPCK mRNA levels
Acid-base homeostasis is essential for survival. When metabolic acidosis is induced by factors such as prolonged starvation, severe shock, high protein diet, or uncontrolled type I diabetes, the kidneys act to compensate for the decreasing pH. Renal catabolism of glutamine, which is sustained through increased expression of phosphoenolpyruvate carboxykinase (PEPCK) and glutaminase (GA), is activated during metabolic acidosis. Mitogen activated protein kinase kinases three and six (MKK3 and MKK6) are thought to play roles in the signal transduction pathway that lead to enhanced PEPCK and ...
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