Potential role of cholesterol in the migration of neurons containing gonadotropin-releasing hormone
Date
2005
Authors
Wadas, Brandon, author
Edelmann, M., author
Spivak, I., author
Feinstein, E., author
Schwarting, G., author
Intlekofer, K., author
Tobet, Stuard, author
Journal Title
Journal ISSN
Volume Title
Abstract
Signaling by Sonic Hedgehog (Shh) is instrumental in the development of midline facial and forebrain structures. Signaling by Shh can be dependent upon conjugation with cholesterol. Structural abnormalities related to cholesterol depletion may be a result of a failure of Shh signaling. Disorders resulting in cholesterol depletion are often characterized in part by developmental malformations, including holoprosencephaly. Neurons that synthesize gonadotropin releasing hormone (GnRH; controls the reproductive axis) originate in the nasal compartment and migrate into the brain along a route that may depend upon proper Shh signaling. The current study was conducted to assess whether cholesterol-depleted enzyme Dhcr24-/- mice would affect the unique migration of GnRH neurons as they migrate to the brain.
Description
Rights Access
Subject
Luteinizing hormone releasing hormone -- Synthesis
Cholesterol