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Potential role of cholesterol in the migration of neurons containing gonadotropin-releasing hormone

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dc.contributor.authorWadas, Brandon, author
dc.contributor.authorEdelmann, M., author
dc.contributor.authorSpivak, I., author
dc.contributor.authorFeinstein, E., author
dc.contributor.authorSchwarting, G., author
dc.contributor.authorIntlekofer, K., author
dc.contributor.authorTobet, Stuard, author
dc.date.accessioned2007-01-03T07:05:28Z
dc.date.available2007-01-03T07:05:28Z
dc.date.issued2005
dc.description.abstractSignaling by Sonic Hedgehog (Shh) is instrumental in the development of midline facial and forebrain structures. Signaling by Shh can be dependent upon conjugation with cholesterol. Structural abnormalities related to cholesterol depletion may be a result of a failure of Shh signaling. Disorders resulting in cholesterol depletion are often characterized in part by developmental malformations, including holoprosencephaly. Neurons that synthesize gonadotropin releasing hormone (GnRH; controls the reproductive axis) originate in the nasal compartment and migrate into the brain along a route that may depend upon proper Shh signaling. The current study was conducted to assess whether cholesterol-depleted enzyme Dhcr24-/- mice would affect the unique migration of GnRH neurons as they migrate to the brain.
dc.description.awardCollege Honors.
dc.format.mediumStudent works
dc.format.mediumposters
dc.identifier.urihttp://hdl.handle.net/10217/569
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2005 Projects
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subject.lcshLuteinizing hormone releasing hormone -- Synthesis
dc.subject.lcshCholesterol
dc.titlePotential role of cholesterol in the migration of neurons containing gonadotropin-releasing hormone
dc.typeStillImage
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBiomedical Sciences
thesis.degree.disciplineVeterinary Medicine and Biomedical Sciences

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Potential role of cholesterol in the migration of neurons containing gonadotropin-releasing hormone
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