Progress toward the synthesis of providencin
Providencin, a highly oxygenated diterpene, was isolated from the sea plume Pseudopterogorgia kallos in 2003 by Rodriguez and co-workers. Providencin was revealed to be a cembrane-based diterpene containing an unprecedented [12.2.0]hexadecane ring-system. Providencin was found to possess anti-cancer activity against human breast (MCF7), lung (NCI-H460) and CNS (SF-268) cancer cell lines. The unique structure and biological activity make providencin an attractive target for total synthesis and our work toward providencin began shortly after its isolation. The initial focus of each approach has ...
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Stevens, Sarah Jean
Wood, John L.