Progress toward the synthesis of providencin
| dc.contributor.author | Stevens, Sarah Jean, author | |
| dc.contributor.author | Wood, John L., advisor | |
| dc.contributor.author | Williams, Robert M., committee member | |
| dc.contributor.author | Kennan, Alan J., committee member | |
| dc.contributor.author | Kurosu, Michio, committee member | |
| dc.contributor.author | Rappé, Anthony K., committee member | |
| dc.date.accessioned | 2007-01-03T05:44:21Z | |
| dc.date.available | 2007-01-03T05:44:21Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Providencin, a highly oxygenated diterpene, was isolated from the sea plume Pseudopterogorgia kallos in 2003 by Rodriguez and co-workers. Providencin was revealed to be a cembrane-based diterpene containing an unprecedented [12.2.0]hexadecane ring-system. Providencin was found to possess anti-cancer activity against human breast (MCF7), lung (NCI-H460) and CNS (SF-268) cancer cell lines. The unique structure and biological activity make providencin an attractive target for total synthesis and our work toward providencin began shortly after its isolation. The initial focus of each approach has centered on the unique trans-fused cyclobutanol moiety. A formal [2 + 2] cycloaddition is our chosen approach to the synthesis of the cyclobutane moiety. Further elaboration of our cyclobutane compounds has led to the synthesis of several highly functionalized intermediates. Our efforts toward the synthesis of providencin are discussed herein. | |
| dc.format.medium | born digital | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier | Stevens_colostate_0053A_10253.pdf | |
| dc.identifier.uri | http://hdl.handle.net/10217/50160 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | [12.2.0]hexadecane | |
| dc.subject | synthesis | |
| dc.subject | Pseudopterogorgia kallos | |
| dc.subject | providencin | |
| dc.title | Progress toward the synthesis of providencin | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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