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    Development of an ultrasensitive ELISA for the detection of Mycobacterium tuberculosis antigens: an impossible challenge or a promising feat?

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    https://hdl.handle.net/10217/235621
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    Abstract
    Tuberculosis (TB) has been classically characterized as a two-state disease with active and latent phases. Latent TB infection (LTBI) is diagnosed by either the tuberculin skin test (TST) or the Interferon Gamma Release Assay (IGRA) test. However, both diagnostic tests are unable to differentially diagnose active TB and LTBI and perform poorly in immunocompromised patients. The TST is further complicated by cross-reactivity with BCG vaccination. Therefore, further diagnostic discovery for LTBI is needed for differential diagnosis and to identify those at risk of progression to active TB for ...
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    Author(s)
    Early, Kala

    Advisor(s)
    Dobos, Karen; Mehaffy, Carolina

    Rights Access
    Embargo Expires: 08/22/2023

    Date Issued
    2022
    Format
    born digital; masters theses
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    • 2020- CSU Theses and Dissertations
    • Theses and Dissertations - Department of Microbiology, Immunology, and Pathology

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