Characterization of pulmonary hypertension status and utilization of multi-omics analyses to discover variants that may inform selection against high mean pulmonary arterial pressure in Angus cattle
This multi-part research characterizes pulmonary hypertension (PH) from a physiologic and genetic point of view using the indicator trait mean pulmonary arterial pressure (PAP). Three aims were designed to address the research objective of investigating the genetics underlying PAP for the purposes of variant discovery. The first aim sought to identify different PAP phenotypes based on altitude and diet during the stocker and finishing phases of production. This longitudinal study evaluated steers with a moderate PAP (41-48 mmHg) from yearling age until harvest, collecting PAP and blood gas ...
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