Uncovering the role of epigenetics in alternative splicing
Alternative Splicing (AS) is a regulated phenomenon that enables a single gene to encode structurally and functionally different biomolecules (proteins, non-coding RNAs etc.), that play important roles in an organism's development and growth. Besides, it has been implicated in multiple diseases including cancer, thalassemia, and spinal muscular atrophy. Recent studies have shown that AS is widespread in both plants and animals. Moreover, it has been reported that splicing occurs co-transcriptionally and that chromatin state is important for understanding the regulation of AS. Most of the previous ...
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