Small RNA methylation in Caenorhabditis elegans
Eukaryotes employ small RNAs and RNA interference (RNAi) for such diverse tasks as regulating gene expression, suppressing viral infections, and defending their genomes from foreign or parasitic sequences such as pseudogenes or transposons. In the germlines of animals, piwi-interacting RNAs (piRNAs) target and silence sequences such as these to ensure that genetic information passes from one generation to the next intact. For many animals, piRNAs must be methylated at their 3' ends to protect them from degradation, and loss of stable piRNAs results in sterility. In this study, we identify a role ...
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