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    Role of prion protein glycosylation in prion propagation, The

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    https://hdl.handle.net/10217/189365
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    Abstract
    Transmissible Spongiform Encephalopathies (TSEs) are a group of neurodegenerative diseases that affect humans and animals alike. TSEs are caused by the accumulation of a disease producing isoform referred to as PrPSc that results from the misfolding of the normal cellular prion protein PrPC. The pathological outcomes of TSEs include amyloid plaque build-up and spongiform degeneration in the brain of infected hosts. Clinical signs of prion disease can vary between TSEs, but often include neurologic impairment that is subtle in onset and tends to progress slowly. Prion diseases are relatively ...
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    Author(s)
    Walker, Deandra Leigh

    Advisor(s)
    Telling, Glenn

    Date Issued
    2018
    Format
    born digital; masters theses
    Collections
    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Department of Microbiology, Immunology, and Pathology

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