Menaquinone-2 and ubiquinone-2 adopt folded, U-shaped conformations contradicting current dogma
The conformations of long polymers of isoprene units such as those found in the side-chains of lipoquinones involved in bacterial (i.e. Mycobacterium tuberculosis) and eukaryotic electron transport systems (ETS) have not been characterized. First, menaquinone-2 and ubiquinone-2 were synthesized then using 1H-1H 2D NOESY and ROESY NMR spectroscopy, we demonstrated that both molecules adopt a folded, U-shaped conformation in solution and within a model membrane interface. These folded conformations are in stark contrast to the extended conformations seen in literature. Folded conformations likely ...
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Koehn, Jordan T.; Crick, Dean C.; Crans, Debbie C.