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Menaquinone-2 and ubiquinone-2 adopt folded, U-shaped conformations contradicting current dogma

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dc.contributor.authorKoehn, Jordan T., author
dc.contributor.authorCrick, Dean C., author
dc.contributor.authorCrans, Debbie C., author
dc.date.accessioned2017-11-13T17:29:04Z
dc.date.available2017-11-13T17:29:04Z
dc.date.issued2017
dc.description.abstractThe conformations of long polymers of isoprene units such as those found in the side-chains of lipoquinones involved in bacterial (i.e. Mycobacterium tuberculosis) and eukaryotic electron transport systems (ETS) have not been characterized. First, menaquinone-2 and ubiquinone-2 were synthesized then using 1H-1H 2D NOESY and ROESY NMR spectroscopy, we demonstrated that both molecules adopt a folded, U-shaped conformation in solution and within a model membrane interface. These folded conformations are in stark contrast to the extended conformations seen in literature. Folded conformations likely affect reactivity, function, and recognition within the ETS and provide insight into drug development of potent inhibitors.en_US
dc.description.awardGreat Minds in Research - Honorable Mention.
dc.format.mediumborn digital
dc.format.mediumStudent works
dc.format.mediumposters
dc.identifier.urihttps://hdl.handle.net/10217/184867
dc.languageEnglishen_US
dc.language.isoengen_US
dc.publisherColorado State University. Librariesen_US
dc.relation.ispartof2017 Projects
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectmenaquinone
dc.subjectubiquinone
dc.subjectfolded conformation
dc.subjectmodel membrane system
dc.subjectNMR spectroscopy
dc.titleMenaquinone-2 and ubiquinone-2 adopt folded, U-shaped conformations contradicting current dogmaen_US
dc.title.alternative157 - Jordan Tyler Koehnen_US
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