Investigating the effects of an endogenous and an exogenous oxidant stressor on protein synthesis in C2C12 myoblasts
Reactive oxygen species (ROS) related signaling is important for stress adaptation. Specifically, ROS may alter protein turnover in a duration dependent manner with acute ROS exposure increasing protein synthesis for cellular adaptation. In vitro experimentation remains a valuable tool investigate the mechanisms underlying ROS-mediated protein synthesis. This study investigates paraquat (PQ), a mitochondrial complex I inhibitor that induces superoxide production, as a potential candidate to induce endogenous ROS production in vitro to simulate an oxidative stress similar to in vivo conditions. ...
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