- ItemOpen AccessMothering behind bars: how addiction, recovery, and incarceration affect mothering(Colorado State University. Libraries, 2016) Willkomm, Larissa A., author; Miller, Katelyn, author; Jacobi, Tobi, authorThe goal of this project is to create a collaborative essay focusing on the experiences of mothering, addiction, and recovery that incarcerated women face. Too often imprisoned women are ignored or criticized, relegated to an untenable space as a statistic or an unnamed casualty (Enos, 2000; Solinger et al, 2010; Haney, 2010; Jacobi and Stanford, 2014). The essay will be co-authored by three women who co-facilitate writing workshops through the Community Literacy Center at a county jail and four women who are held at the jail. This core group will offer their own views, their own definitions of addiction, their own experiences with mothering, and what these terms mean to them. The group will begin with stories, stories that unfold through their essay and that have been published in the SpeakOut journals that emerge twice annually across more than a decade of dedicated writing workshops. The writers are committed to collaborative authorship and will use a range of participatory methods to invite imprisoned mothers to co-author this story. They will distribute a call for contributions in the housing unit and invite the lead co-authors to engage in both reflection and autoethnographic/lifewriting. As a team the writers will review selected published poems and writing from the Speak/Out Journal in order to understand the breadth of experience that women have chosen to document. This essay will not only offer up those voices, but will actively engage currently incarcerated women in the shaping and crafting of the writing and perspectives the writers offer.
- ItemOpen AccessChemotherapeutic responses in canine lymphoma models after treatment with the CHOP protocol(Colorado State University. Libraries, 2016) Ramirez, Dominique, author; Wittenburg, Luke, authorIn both human and veterinary oncology, multi-drug resistance is a phenomenon where a cancer gains a cyto-protective effect against chemotherapeutics. Resistance is often witnessed when remitted cancers relapse and become untreatable. As an example, canine lymphomas are notorious for relapsing after treatment with the multi-drug CHOP protocol. While canonical drug efflux transporters have been implicated with the chemo-resistance phenotype, there are other transporters which might also contribute. Recent research has demonstrated that exposure to chemotherapeutics results in epigenetic changes to transporter gene expression; this could be a possible route for acquiring the resistance phenotype. What is still unknown, however, is a mechanistic understanding of the chemotherapy-transporter expression relationship. To address this void, we are focusing our research on three questions: 1) What are the temporal fluctuations in transporter expression following exposure to multi-drug regimens? 2) What patterns of epigenetic markers on transporter genes promote altered expression? 3) How does transporter expression correlate to protein levels in chemo-resistant lymphomas? We will address each of these questions using a panel of four chemo-sensitive canine lymphomas as our models, and the CHOP protocol as our drug regimen. We will expose the lymphomas to combinations of the CHOP protocol to mimic short- and long-term treatments, and monitor transporter expression via QT-PCR, and epigenetic changes via ChIP-assays. Additionally, protein levels will be monitored with LC-MS/MS methods to correlate expression with translation. We hypothesize that changes in transporter expression exhibit temporal and drug-dependent patterns.
- ItemOpen AccessThe woman who wanted to be a soldier(Colorado State University. Libraries, 2016) Leskanich, Ivana, authorThis essay serves as a character analysis for Desdemona in William Shakespeare's Othello. It argues that Desdemona primarily wishes to be a soldier rather than acquiescing to her wifely role. She faces greater disadvantages than her husband Othello due to the fact that she is, first and foremost, a woman and cannot command multiple roles.