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Permanent URI for this collectionhttps://hdl.handle.net/10217/196418

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Browsing Research Data by Author "Magzamen, Sheryl"

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    ItemOpen Access
    Data associated with "Health and environmental justice implications of retiring two coal‐fired power plants in the southern Front Range region of Colorado"
    (Colorado State University. Libraries, 2019) Martenies, Sheena; Akherati, Ali; Jathar, Shantanu; Magzamen, Sheryl
    Despite improvements in air quality over the past 50 years, ambient air pollution remains an important public health issue in the United States. In particular, emissions from coal-fired power plants still have a substantial impact on both nearby and regional populations. Of particular concern is the potential for this impact to fall disproportionately on low-income communities and communities of color. We conducted a quantitative health impact assessment to estimate the health benefits of the proposed decommissioning of coal-fired boilers at two electricity generating stations in the Southern Front Range region of Colorado. We estimated changes in exposures to fine particulate matter (PM2.5) and ozone due to reductions in emission using the Community Multiscale Air Quality model and predicted avoided health impacts and related economic values. In addition to estimating health benefits of reduced emissions, we assessed the distribution of these benefits by population-level socioeconomic status using concentration curves. Across the study area, decommissioning the power plants would result in 4 (95% CI: 2 – 6) avoided premature deaths each year due to reduced PM2.5 exposures and greater reductions in hospitalizations and other morbidities. Health benefits resulting from the modeled shutdowns were greatest in areas with lower median incomes, lower percentages of high school graduates, and higher proportions of households with incomes below the poverty line. However, in our study area, we did not observe higher benefits when examining area-level percentage of residents of color, largely due to the distribution of the smaller proportion of the population in the region that identifies as non-White. Our results suggest that decommissioning the power plants in the southern Front Range and replacing them with zero-emissions sources could have broad public health benefits for residents of Colorado, with larger benefits for those that are socially disadvantaged and historically bear greater environmental pollution burdens. These results also suggested that researchers and decision makers need to consider the unique demographics of their study areas to ensure that important opportunities to reduce health disparities associated with point-source pollution.
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    ItemOpen Access
    Dataset associated with "Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors"
    (Colorado State University. Libraries, 2020) Labadie, Julia D.; Elvers, Ingegerd; Spencer Feigelson, Heather; Magzamen, Sheryl; Yoshimoto, Janna; Dossey, Jeremy; Burnett, Robert; Avery, Anne C.
    Background: T zone lymphoma (TZL), a histologic variant of peripheral T cell lymphoma, represents about 12% of all canine lymphomas. Golden Retrievers appear predisposed, representing over 40% of TZL cases. Prior research found that asymptomatic aged Golden Retrievers frequently have populations of T zone-like cells (phenotypically identical to TZL) of undetermined significance (TZUS), potentially representing a pre-clinical state. These findings suggest a genetic risk factor for this disease and caused us to investigate potential genes of interest. Methods: Privately-owned U.S. Golden Retrievers were categorized as TZL (n=95), TZUS (n=142), or control (n=101) using flow cytometry and genotyped using the Illumina CanineHD BeadChip. Single nucleotide polymorphism (SNP)-specific associations were evaluated using a mixed linear model adjusting for population stratification. Associated regions were subsequently sequenced using a custom sequence capture array (NimbleGen SeqCap EZ Developer Kit) on an Illumina NextSeq 500. Results: We found association with genome-wide significance in regions on chromosomes 8 and 14. The chromosome 14 peak included four SNPs (Odds Ratio=1.18–1.19, p=.3x10-5–5.1x10-5) near three hyaluronidase genes (SPAM1, HYAL4, and HYALP1). Targeted resequencing of this region identified missense mutations in all three genes; the variant in SPAM1 was predicted to be damaging. These mutations were also associated with risk for mast cell tumors among Golden Retrievers in an unrelated study. The chromosome 8 peak contained 7 SNPs (Odds Ratio=1.24–1.42, p= 2.7x10-7–7.5x10-5) near genes involved in thyroid hormone regulation (DIO2 and TSHR). A prior study from our laboratory found hypothyroidism is inversely associated with TZL risk. No coding mutations were found with targeted resequencing but identified variants may play a regulatory role for all or some of the genes. Conclusions: The pathogenesis of canine TZL may be related to hyaluronan breakdown and subsequent production of pro-inflammatory and pro-oncogenic byproducts. The association on chromosome 8 may indicate thyroid hormone is involved in TZL development, consistent with findings from a previous study evaluating epidemiologic risk factors for TZL. Future work is needed to elucidate these mechanisms.