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Development of an artificial temporomandibular joint disc replacement

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dc.contributor.authorKuiper, Jason Paul, author
dc.contributor.authorPuttlitz, Christian M., advisor
dc.contributor.authorPrawel, David, committee member
dc.contributor.authorMcGilvray, Kirk, committee member
dc.contributor.authorHenry, Charles, committee member
dc.date.accessioned2023-08-28T10:29:15Z
dc.date.available2025-08-28T10:27:54Z
dc.date.issued2023
dc.description.abstractThe temporomandibular joint (TMJ) is a complex bilateral ginglymoarthroidal joint containing a fibrocartilaginous disc and is essential for chewing, speaking, and swallowing. Due to the high loading frequency, small imbalances in joint homeostasis can overcome the natural capacity for adaptation and lead to a cascade of degenerative changes. For progressive TMJ disorders, resection of the TMJ disc is the leading treatment, but disc resection inherently increases stress and friction on the articular cartilage surfaces, leading to a progression to total joint replacement in 11.7% of patients. The current methods of treatment for disorders of the TMJ musculoskeletal complex are predominantly palliative and do not reliably address disorders of arthrogenous origin. Unfortunately, no synthetic TMJ disc replacements currently exist due to profound implant failures in earlier attempts. Introduction of a robust artificial TMJ disc replacement after resection will prevent further joint degradation and improve patient outcomes. Rigorous preclinical evaluation of artificial TMJ disc replacement strategies must be conducted to support future translation to humans. Therefore, the following aims are proposed: (1) Characterize the biomechanical behavior of the ovine temporomandibular joint soft tissues, (2) identify and evaluate a material candidate for a temporomandibular joint disc replacement, (3) develop in silico and in vitro methods for evaluating design candidates for artificial TMJ disc replacement, and (4) implement a temporomandibular joint disc replacement strategy in an ovine model.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierKuiper_colostate_0053A_17839.pdf
dc.identifier.urihttps://hdl.handle.net/10217/237019
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.rights.accessEmbargo expires: 08/28/2025.
dc.subjectfinite element
dc.subjectpolyvinyl alcohol hydrogel
dc.subjectartificial disc replacement
dc.subjecttemporomandibular joint disc
dc.subjectmechanical characterization
dc.titleDevelopment of an artificial temporomandibular joint disc replacement
dc.typeText
dcterms.embargo.expires2025-08-28
dcterms.embargo.terms2025-08-28
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineMechanical Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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