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Development of surface modifications on titanium for biomedical applications

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dc.contributor.authorMaia Sabino, Roberta, author
dc.contributor.authorPopat, Ketul C., advisor
dc.contributor.authorMartins, Alessandro F, advisor
dc.contributor.authorHerrera-Alonso, Margarita, committee member
dc.contributor.authorLi, Yan Vivian, committee member
dc.contributor.authorWang, Zhijie, committee member
dc.date.accessioned2022-01-07T11:30:40Z
dc.date.available2023-01-06T11:30:40Z
dc.date.issued2021
dc.description.abstractFor decades, titanium-based implants have been largely employed for different medical applications due to their excellent mechanical properties, corrosion resistance, and remarkable biocompatibility with many body tissues. However, even titanium-based materials can cause adverse effects which ultimately lead to implant failure and a need for revision surgeries. The major causes for implant failure are thrombus formation, bacterial infection, and poor osseointegration. Therefore, it is essential to develop multifunctional surfaces that can prevent clot formation and microbial infections, as well as better integrate into the body tissue. To address these challenges, two different surface modifications on titanium were investigated in this dissertation. The first one was the fabrication of superhemophobic titania nanotube (NT) surfaces. The second approach was the development of tanfloc-based polyelectrolyte multilayers (PEMs) on NT. The hemocompatibility and the ability of these surfaces to promote cell growth and to prevent bacterial infection were investigated. The results indicate that both surface modifications on titanium enhance blood compatibility, and that tanfloc-based PEMs on NT improve cell proliferation and differentiation, and antibacterial properties, thus being a promising approach for designing biomedical devices.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierMaiaSabino_colostate_0053A_16894.pdf
dc.identifier.urihttps://hdl.handle.net/10217/234281
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectsuperhemophobic surfaces
dc.subjecttitania nanotubes
dc.subjectlayer-by-layer
dc.subjecttitanium surfaces
dc.subjecttanfloc
dc.titleDevelopment of surface modifications on titanium for biomedical applications
dc.typeText
dcterms.embargo.expires2023-01-06
dcterms.embargo.terms2023-01-06
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineAdvanced Materials Discovery
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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