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Physical and chemical characteristics behind membrane interactions of small molecules and electron transporters

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dc.contributor.authorPeters, Benjamin J., author
dc.contributor.authorCrans, Debbie C., advisor
dc.contributor.authorCrick, Dean C., committee member
dc.contributor.authorReynolds, Melissa M., committee member
dc.contributor.authorRoss, Eric D., committee member
dc.date.accessioned2019-01-07T17:19:25Z
dc.date.available2020-01-03T17:19:53Z
dc.date.issued2018
dc.description.abstractThere are many types of molecules that interact with and within membranes whereas many factors can dictate how they interact with membranes. Often, the interactions with the membrane interface can affect the mechanism of action of these molecules. Here, the interactions of small molecules and an electron transporter with model membranes under varying conditions are described. In the first chapter, the pH dependence of membrane association of a commonly used food preservative, benzoic acid was discussed and compared to the mechanism of action of general weak acid preservatives. Next the interactions of many structurally very similar compounds with model membranes were compared. These studies outline the importance of both the environment and that by just altering the molecules slightly, the interactions of the molecules can be changed. Chapter 4 outlines the importance of lipid density on the interactions of the electron transporter used within the electron transport system of Mycobacterium tuberculosis (menaquinone-9) to show that menaquinone is capable of membrane transport of protons and electrons. Together, these studies show how interactions and diffusion across membranes are not straight forward and more research is necessary to fully understand the interactions of molecules with cell membranes.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierPeters_colostate_0053A_15182.pdf
dc.identifier.urihttps://hdl.handle.net/10217/193151
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectisoniazid
dc.subjectlipid interactions
dc.subjectreverse micelle
dc.subjectLangmuir monolayer
dc.subjectdrug uptake
dc.subjectmembrane
dc.titlePhysical and chemical characteristics behind membrane interactions of small molecules and electron transporters
dc.typeText
dcterms.embargo.expires2020-01-03
dcterms.embargo.terms2020-01-03
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineChemistry
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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