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Synthetic control of magnetic resonance properties towards metal-based electron paramagnetic resonance imaging

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dc.contributor.authorCampanella, Anthony John, author
dc.contributor.authorZadrozny, Joseph, advisor
dc.contributor.authorShores, Matthew, committee member
dc.contributor.authorBandar, Jeff, committee member
dc.contributor.authorWu, Mingzhong, committee member
dc.date.accessioned2023-08-28T10:29:10Z
dc.date.available2025-08-28T10:27:54Z
dc.date.issued2023
dc.description.abstractElectron paramagnetic resonance imaging (EPRI) is the electron-spin analogue to conventional biological (nuclear) magnetic resonance imaging (MRI) whereby unpaired electron spins are probed in order to generate an image. The greater sensitivity of electron spins to their environment can thus be leveraged to capture detailed chemical information from the surroundings, producing an image of the local physiology that adds an extra dimension to the already powerful anatomical information gained from MRI. To move EPRI a step closer to common utilization, paramagnetic probes must be developed to sense the local environment using safe low-frequency microwaves at high (ca. 1.5 T) magnetic fields. Paramagnetic metal complexes are ideal candidates due to their electronic structures but have not been investigated for such purposes. The goal of this dissertation is to develop fundamental design principles to improve the utility of metal complexes as EPRI probes. Presented herein is the first comprehensive collection of experimental investigations to this end. Firstly, a method for improving signal sharpness is investigated, where exhaustive spectroscopic and computational studies suggest differences in relaxation dynamics as being a key factor in spectral linewidth (Chapters 2 and 3). A highly tunable clathrochelate structure is developed, inducing an unusual coordination geometry around the Ni(II) ion affording an 11 cm−1control of zero-field splitting (Chapter 4). The temperature dependence of zero-field splitting is examined in a series of Mn(II) complexes where an unusually high temperature sensitivity is found in the solid state (Chapter 5). Finally, the utility of metal complexes as environmental sensors is demonstrated with a pair of Mn(II) complexes showing that increasing magnetic anisotropy is a design strategy for enhancing microviscosity sensitivity (Chapter 6). The learned design principles will serve as a foundation for the design of metal-based EPRI agents towards improving the non-invasive diagnostic capabilities.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierCampanella_colostate_0053A_17778.pdf
dc.identifier.urihttps://hdl.handle.net/10217/236987
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.rights.accessEmbargo expires: 08/28/2025.
dc.subjectelectron paramagnetic resonance imaging
dc.subjectelectron paramagnetic resonance
dc.subjectmetal complex
dc.titleSynthetic control of magnetic resonance properties towards metal-based electron paramagnetic resonance imaging
dc.typeText
dcterms.embargo.expires2025-08-28
dcterms.embargo.terms2025-08-28
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineChemistry
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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