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Simplified membrane-like systems describing the physical behaviors of cholesterol and anti-diabetic drugs

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dc.contributor.authorTrujillo, Alejandro M., author
dc.contributor.authorCrans, Debbie C., advisor
dc.contributor.authorRoess, Deborah A., committee member
dc.contributor.authorFrye, Melinda A., committee member
dc.contributor.authorVan Orden, Alan K., committee member
dc.date.accessioned2007-01-03T06:09:35Z
dc.date.available2007-01-03T06:09:35Z
dc.date.issued2013
dc.description.abstractThis work evaluates the properties contributing to natural membrane permeability by using simplified systems. Absorption mechanisms are a critical step in evaluating the action of orally active drugs. Reverse micelles (RMs) were used as a membrane-like model to analyze the permeation through spectroscopy. The properties exerted by the ligand and ligand substituents were evaluated in the context of membrane permeation. The polydentate ligand of anti diabetic dipicolinatooxvanadium(V) [VO2dipic])-, 2,6-pyridinedicarboxylate (dipic2-) was observed for permeability in sodium bis(2-ethylhexyl)sulfosuccinate (AOT) RMs. Measurements using proton nuclear magnetic resonance (1H NMR) spectroscopy revealed the permeation and hydrophobic stability at physiological pH for dipic2-. Substituents, NH2, OH, H, Cl, NO2 were evaluated forinfluencing the stability and permeability of [VO2(dipic)]-; in AOT RMs. Using infrared spectroscopy (IR), substituent changes significantly influenced the permeation of the vanadium complex series. Properties contributing to the membrane permeation of drugs may also be altered by membrane composition. Cholesterol is present in intestinal membranes and is known to possess properties reducing permeability. A system composed of cetyltrimethylammonium bromide (CTAB), 1-pentanol, cholesterol, and an aqueous phase formed RMs characterized by NMR and dynamic light scattering (DLS). Cholesterol altered the RM structure and proton transfer rates between the water and 1-pentanol of the system. Combined, this work illustrates that ligands, substituents, and membrane components influence the uptake of orally administered drugs.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierTrujillo_colostate_0053A_12092.pdf
dc.identifierETDF2013500352CMBO
dc.identifier.urihttp://hdl.handle.net/10217/80984
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectabsorption
dc.subjectanti-diabetic
dc.subjectmicroemulsion
dc.subjectpermeability
dc.subjectreverse micelle
dc.subjectvanadium
dc.titleSimplified membrane-like systems describing the physical behaviors of cholesterol and anti-diabetic drugs
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineCell and Molecular Biology
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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