Repository logo
 

Nanofiber based smart wound dressing combined with bacteria detection and drug delivery

Simple item page
dc.contributor.authorHassan, Faqrul, author
dc.contributor.authorLi, Yan Vivian, advisor
dc.contributor.authorPark, Juyeon, committee member
dc.contributor.authorPopat, Ketul, committee member
dc.date.accessioned2018-09-10T20:05:54Z
dc.date.available2018-09-10T20:05:54Z
dc.date.issued2018
dc.description.abstractSince the emergence of Nanotechnology in the past decades, the development and design of nanofibers demonstrated the great potential for applications in wound treatment. Proliferation of bacteria in wound site is a major challenge in combating wounds. Bio-sensing wound dressing composed of nanofibers has proven to be an effective tool in detecting bacterial presence at wound sites. Though wound dressing with antibacterial property is available but they are not quite effective in terms of bioavailability and sustained release of drugs. Biodegradable polymeric nanoparticles have been proven to increase bioavailability, encapsulation, and control release of drugs with less toxic properties. In this study, poly diacetylene (PDA)-based composite nanofibers were prepared to study the microstructure and mechanical properties, and to investigate relationship between these two. It was found that mixing polyurethane (PU) polymer with the PDA yielded better mechanical properties as PU and PDA mixed homogeneously and this helped to form large crystalline regions in the fiber microstructure. In the second part of this thesis, poly(D, Lactide-co-glycolide) acid (PLGA) nanoparticles were synthesized by double emulsion solvent evaporation technique to encapsulate hydrophilic gentamicin antibiotics. The effects of different formulation parameters on the particle size and structure were examined thoroughly which included copolymer ratios of PLGA, molecular weight and concentration of stabilizing agents or surfactants, volume of both aqueous and organic phase, sonication and stirring rate and time. The molecular weight and concentration of surfactants had the most impact on the size and morphology of particles. Higher molecular weight of surfactants caused agglomeration of particles. Increasing the concentration of surfactants resulted in smaller particles. PLGA particles with different morphologies were obtained where the average size ranged 300 nm to several microns.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierHASSAN_colostate_0053N_15096.pdf
dc.identifier.urihttps://hdl.handle.net/10217/191490
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectcomposite fibers
dc.subjectmicromechanical properties
dc.subjectpolydiacetylene
dc.subjectdouble emulsion
dc.subjectAFM force spectrometry
dc.subjectPLGA nanoparticles
dc.titleNanofiber based smart wound dressing combined with bacteria detection and drug delivery
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineDesign and Merchandising
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
HASSAN_colostate_0053N_15096.pdf
Size:
8.75 MB
Format:
Adobe Portable Document Format
Download

Collections

2000-2019
Theses and Dissertations