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Ivermectin mass drug administration to humans for malaria parasite transmission control

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dc.contributor.authorKobylinski, Kevin, author
dc.contributor.authorFoy, Brian D., advisor
dc.contributor.authorEisen, Lars, committee member
dc.contributor.authorHuyvaert, Kathryn P., committee member
dc.contributor.authorRosenberg, Ronald, committee member
dc.date.accessioned2007-01-03T05:47:48Z
dc.date.available2007-01-03T05:47:48Z
dc.date.issued2011
dc.description.abstractEvery year, an estimated 500 million people are afflicted with malaria worldwide, killing more than one million people, most of whom are children in sub-Saharan Africa. The current malaria eradication program requires novel vector control methods to reduce the transmission of Plasmodium, the causative agent of malaria. These new methods must: target exophagic and exophilic Plasmodium vectors, integrate with current vector control efforts, be evaluated in the field in combination with other interventions, evade potential behavioral mechanisms that mosquitoes may evolve to avoid the intervention, new agents should have different modes of action, reduce the risk of physiological resistance development, and affect vector population age structure. This dissertation addresses how ivermectin mass drug administration, meets and exceeds all of these issues. Laboratory-based experiments demonstrated that ivermectin at human relevant pharmacokinetics affects Anopheles gambiae s.s. survivorship and that cumulative ivermectin blood meals compound mortality, blood feeding frequency, knockdown, and recovery. Field-based experiments demonstrate that ivermectin mass drug administration to humans reduces the survivorship of wild-caught Anopheles gambiae s.s. and probably Anopheles arabiensis up to six days post-administration. Most importantly, ivermectin mass drug administration to humans was shown to reduce the proportion of field-caught Plasmodium falciparum-infectious Anopheles gambiae s.s. for at least 12 days post-treatment. Ivermectin mass drug administration could be a powerful addition to malaria eradication campaign efforts.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierKobylinski_colostate_0053A_10591.pdf
dc.identifier.urihttp://hdl.handle.net/10217/51799
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectmalaria
dc.subjectivermectin
dc.subjectcontrol
dc.subject.lcshPlasmodium
dc.subject.lcshAnopheles gambiae
dc.titleIvermectin mass drug administration to humans for malaria parasite transmission control
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineMicrobiology, Immunology, and Pathology
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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