Caffeine augments the lactate and interleukin-6 response to moderate-intensity exercise in males but not females
| dc.contributor.author | Abbotts, Kieran Shay Struebin, author | |
| dc.contributor.author | Bell, Christopher, advisor | |
| dc.contributor.author | Hamilton, Karyn, committee member | |
| dc.contributor.author | Melby, Christopher, committee member | |
| dc.date.accessioned | 2022-05-30T10:21:26Z | |
| dc.date.available | 2024-05-24T10:21:26Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | The release of interleukin (IL)-6 from contracting skeletal muscle is thought to contribute to some of the health benefits bestowed by exercise. This IL-6 response appears proportional to exercise volume. Unfortunately, high volumes of exercise are not feasible for all people. Caffeine augments the magnitude of increase in circulating concentration of IL-6 in response to high-intensity and long-duration exercise, in males. Caffeine is also known to increase circulating concentrations of lactate during exercise. One of the mechanisms thought to contribute to IL-6 release from exercising skeletal muscle is lactate production. We hypothesized that caffeine, ingested prior to moderate-intensity exercise, would lead to greater circulating concentrations of lactate and IL-6 in a study population comprising both males and females. 15 healthy adults (9 males and 6 females, aged 26±7 years, (mean ± SD)) completed 30-minutes of moderate-intensity cycle ergometer exercise, equivalent to the ventilatory threshold, after ingesting either caffeine (6 mg/kg) or placebo. Arterialized-venous blood was collected throughout each of the exercise sessions. Compared with placebo, caffeine increased end-exercise circulating concentrations of lactate (5.72±3.95 vs. 7.14±4.66 mmol/L, P<0.001) but not end-exercise IL-6 (1.84±0.97 vs. 2.37±1.04 pg/mL, P=0.139). However, when females were excluded from the analysis, caffeine augmented (P=0.04) the magnitude of increase of end-exercise IL-6 concentration (1.80±0.86 vs. 2.57±1.21 pg/mL); this effect was further exaggerated after 30-minutes of inactive recovery (3.81±2.32 vs. 5.06±3.22 pg/mL). Noteworthy, caffeine evoked greater end-exercise lactate concentrations in data sets containing only males (P=0.02) and only females (P=0.002) but did not influence the IL-6 response in females (P=0.94). Our preliminary data imply that in males unable/unwilling to perform high-intensity and/or long-duration exercise, caffeine may potentially enhance the IL-6 mediated health benefits of relatively short, moderate-intensity exercise. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier | Abbotts_colostate_0053N_17123.pdf | |
| dc.identifier.uri | https://hdl.handle.net/10217/235206 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2020- | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.rights.access | Embargo Expires: 05/24/2024 | |
| dc.subject | IL-6 | |
| dc.subject | physical activity | |
| dc.subject | cycling | |
| dc.subject | skeletal muscle | |
| dc.subject | myokines | |
| dc.title | Caffeine augments the lactate and interleukin-6 response to moderate-intensity exercise in males but not females | |
| dc.type | Text | |
| dcterms.embargo.expires | 2024-05-24 | |
| dcterms.embargo.terms | 2024-05-24 | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Health and Exercise Science | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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