Repository logo
 

Equine fecal microbiota changes associated with anthelmintic administration

Simple item page
dc.contributor.authorKunz, Isabelle, author
dc.contributor.authorColeman, Stephen, advisor
dc.contributor.authorHess, Tanja, committee member
dc.contributor.authorHassel, Diana, committee member
dc.contributor.authorMetcalf, Jessica, committee member
dc.date.accessioned2018-09-10T20:05:39Z
dc.date.available2020-09-06T20:05:39Z
dc.date.issued2018
dc.description.abstractThe equine gastrointestinal tract contains a complex ecosystem comprised of microorganisms and intestinal helminth parasites. Increasing evidence suggests that horses rely on their gastrointestinal microbial populations for many aspects of metabolic and immune function. Furthermore, interactions between the microbes, helminths, and their host may impact these functions, which are vital to maintaining gastrointestinal homeostasis. The use of anthelmintic drugs is a common practice of intestinal helminth parasite control in domestic horse health management. The use of anthelmintic drugs is very effective for controlling the burden of parasitic infection and associated clinical signs, however anthelmintic administration has also been associated with gastrointestinal disturbances in the horse. The potential effects of anthelmintic drug administration on the equine gastrointestinal microbiota and its' role in homeostasis is not yet understood. The objective of research presented in this thesis is to investigate the impact of anthelmintic administration on the equine gastrointestinal microbiota. This goal was addressed in two main studies, which used 16S rRNA amplicon sequencing to identify and describe the microbial populations present in equine fecal samples. The first study described is a pilot project which aimed to characterize the impact of anthelmintic treatment on the fecal microbiota of horses without an observable helminth infection. The results of this study indicated that subtle differences in the microbial community composition and structure are detectable between samples collected before and after anthelmintic treatment. A second study was then conducted as a follow-up to the pilot which included horses with varying detectable levels of helminth infection as determined by fecal egg counts. Results of the second study further demonstrated microbiota changes following anthelmintic treatment, while also suggesting that the most notable effects of anthelmintic treatment may be observed in fecal samples between 48 and 72 hours post-treatment. The results of these studies suggest that anthelmintic treatment may be associated with changes in the equine fecal microbiota.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierKunz_colostate_0053N_15060.pdf
dc.identifier.urihttps://hdl.handle.net/10217/191464
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectanthelmintic
dc.subjecthorse
dc.subjectmicrobiota
dc.subjectequine
dc.subject16S
dc.subjectmicrobiome
dc.titleEquine fecal microbiota changes associated with anthelmintic administration
dc.typeText
dcterms.embargo.expires2020-09-06
dcterms.embargo.terms2020-09-06
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineAnimal Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kunz_colostate_0053N_15060.pdf
Size:
1.72 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

2000-2019
Theses and Dissertations