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Coagulation abnormalities in Ehrlichia canis-infected dogs and detection and dynamics of anti-platelet antibodies in thrombocytopenic dogs

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dc.contributor.authorShropshire, Sarah, author
dc.contributor.authorLappin, Michael, advisor
dc.contributor.authorDow, Steve, committee member
dc.contributor.authorOlver, Christine, committee member
dc.contributor.authorWebb, Craig, committee member
dc.contributor.authorAmes, Marisa, committee member
dc.date.accessioned2018-09-10T20:05:36Z
dc.date.available2018-09-10T20:05:36Z
dc.date.issued2018
dc.description.abstractVector-borne diseases affect millions of people and domestic animals worldwide resulting in significant morbidity and mortality rates. In dogs, vector-borne diseases such as Ehrlichia canis can cause a myriad of clinical signs (lethargy, weight loss, and epistaxis) and hematological abnormalities (hyperglobulinemia, thrombocytopenia, and anemia). It has been previously reported that E. canis results in systemic inflammation and vasculitis as well as the formation of immunoglobulin associated platelets or anti-platelet antibodies. It has been theorized that anti-platelet antibodies can deleteriously affect platelet function and if concurrent significant thrombocytopenia is present, signs of bleeding may manifest. However, anti-platelet antibodies and thrombocytopenia can occur in a variety of disease processes in the dog including other vector-borne diseases, neoplasia, and idiopathic primary immune syndromes. Thrombocytopenia is also one of the most common acquired hemostatic abnormality observed in dogs. Consequently, determining the underlying cause and mechanism for thrombocytopenia in dogs can represent a frequent diagnostic challenge. Additionally, inflammation is often present in dogs with thrombocytopenia due to various causes. Inflammation and immune system processes directly affect hemostasis which can lead to derangements in the coagulation system resulting in clinical signs of bleeding or thrombosis. The goals of the research described in this dissertation were to investigate the dynamic changes of anti-platelet antibodies in thrombocytopenic dogs and the changes that occur in the coagulation system during a vector-borne infection such as E. canis in dogs.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierShropshire_colostate_0053A_15056.pdf
dc.identifier.urihttps://hdl.handle.net/10217/191460
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectEhrlichia canis
dc.subjectthrombocytopenia
dc.subjectwhole blood impedance platelet aggregometry
dc.subjectflow cytometry
dc.subjectcoagulation
dc.subjectthromboelastography
dc.titleCoagulation abnormalities in Ehrlichia canis-infected dogs and detection and dynamics of anti-platelet antibodies in thrombocytopenic dogs
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineClinical Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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