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Inhalational antibiotic therapy for treatment of chronic pulmonary Mycobacterium abscessus disease in mice

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dc.contributor.authorPearce, Camron, author
dc.contributor.authorGonzalez-Juarrero, Mercedes, advisor
dc.contributor.authorJackson, Mary, committee member
dc.contributor.authorVolckens, John, committee member
dc.date.accessioned2020-01-13T16:41:43Z
dc.date.available2022-01-07T16:41:53Z
dc.date.issued2019
dc.description.abstractMycobacterium abscessus (M. abscessus) is a nontuberculous mycobacterium that causes chronic pulmonary infections. Due to M. abscessus's intrinsic antibiotic resistance, treatment is often complex with low cure rates. Tigecycline, a glycylcycline class antibiotic, demonstrates bactericidal effects against M. abscessus without eliciting bacterial resistance mechanisms, however, this antibiotic requires intravenous administration and causes significant side effects that limit its use. Here, we tested the hypothesis that tigecycline administered via inhalation has the potential to maximize the bactericidal effect while reducing side effects. GM-CSF knockout mice with pulmonary M. abscessus infection were treated by intrapulmonary tigecycline aerosols in 0.25 mg, 1.25 mg, and 2.50 mg doses for 28 days. Assessment of pulmonary bacterial burden after full treatment duration shows that inhaled tigecycline is highly effective, dose-dependent, and well tolerated. We concluded that inhaled tigecycline represents a viable treatment option for M. abscessus pulmonary disease. Future studies should address the pharmacokinetics, and ultimately, translation into clinical trials.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierPearce_colostate_0053N_15753.pdf
dc.identifier.urihttps://hdl.handle.net/10217/199782
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectMycobacterium abscessus
dc.subjectnontuberculous
dc.subjectinhaled therapy
dc.subjecttigecycline
dc.subjectMycobacterium infection
dc.titleInhalational antibiotic therapy for treatment of chronic pulmonary Mycobacterium abscessus disease in mice
dc.typeText
dcterms.embargo.expires2022-01-07
dcterms.embargo.terms2022-01-07
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineMicrobiology, Immunology, and Pathology
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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