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TRPM4 in cerebral artery smooth muscle cells

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dc.contributor.authorGonzales, Albert Louis, author
dc.contributor.authorEarley, Scott, advisor
dc.contributor.authorAmberg, Gregory C., committee member
dc.contributor.authorDinenno, Frank A., committee member
dc.contributor.authorRash, John E., committee member
dc.contributor.authorTamkun, Michael M., committee member
dc.date.accessioned2007-01-03T08:26:21Z
dc.date.available2007-01-03T08:26:21Z
dc.date.issued2012
dc.description.abstractCerebral arterial tone is dependent on the depolarizing and hyperpolarizing currents regulating membrane potential and governing the influx of Ca2+ needed for smooth muscle contraction. Several ion channels have been proposed to contribute to membrane depolarization, but the underlying molecular mechanisms are not fully understood. In this review, we will discuss the historical and physiological significance of the Ca2+-activated cation channel, TRPM4, in regulating membrane potential of cerebral artery smooth muscle cells. As a member of the recently described transient receptor potential super family of ion channels, TRPM4 possesses the biophysical properties and upstream cellular signaling and regulatory pathways that establish it as a major physiological player in smooth muscle membrane depolarization.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierGonzales_colostate_0053A_11544.pdf
dc.identifierETDF2012500301BIOS
dc.identifier.urihttp://hdl.handle.net/10217/71560
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectcalcium
dc.subjectTRPM4
dc.subjectsmooth muscle cells
dc.subjectmyogenic response
dc.titleTRPM4 in cerebral artery smooth muscle cells
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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