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Characterization of biased partner choice in mitotic non-allelic homologous recombination of Saccharomyces cerevisiae

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dc.contributor.authorMerriman, Sean, author
dc.contributor.authorArgueso, Juan Lucas, advisor
dc.contributor.authorMarkus, Steven, committee member
dc.contributor.authorNishimura, Erin, committee member
dc.contributor.authorWiese, Claudia, committee member
dc.date.accessioned2023-06-01T23:56:04Z
dc.date.available2023-06-01T23:56:04Z
dc.date.issued2023
dc.description.abstractUsing yeast as a model in which to study copy number variation (CNV)-generating mutations, the J.L. Argueso lab has discovered that a specific region of S. cerevisiae genome (the right arm of chromosome 7; Chr7R) is much more susceptible to sustaining deletions as a translocation recipient than other apparently similar segments of the genome. Further, Chr7R acquires amplifications as a translocation donor less frequently than other chromosomes. To begin unraveling the cause of this unusual behavior, we evaluated the effect of several candidate genes involved in chromatin mobility and sister chromatid cohesion on the mutational spectra involving Chr7R. Our results suggest that regulatory factors of chromatin mobility or sister chromatid cohesion affect the outcomes of HR-mediated repair events at Ch7R. We are hopeful that our findings will open a window into the fundamental cellular processes that are responsible for CNVs found in eukaryotic genomes, and inform translational implications for modeling this class of mutation in cancer.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierMerriman_colostate_0053A_17713.pdf
dc.identifier.urihttps://hdl.handle.net/10217/236690
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.titleCharacterization of biased partner choice in mitotic non-allelic homologous recombination of Saccharomyces cerevisiae
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineCell and Molecular Biology
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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