Effect of titania nanotubes on the cifferentiation of adipose derived stem cells
Date
2017
Authors
Cowden, Kari, author
Dias-Netipanyj, Marcela Ferreira, author
Popat, Ketul C., author
Journal Title
Journal ISSN
Volume Title
Abstract
Titanium orthopedic implants still experience a high level of failure at the implant site. Earlier studies have shown that nanostructuring the surface of titanium can enhance stem cell migration, proliferation, and differentiation. However, the ideal size of this nanostructuring is still disputed. In this study three distinct diameter controlled nanotube (NT) surfaces were fabricated on titanium sheets using an anodization technique and varied voltages. Adipose-derived stem cells (ADSC) were cultured and proliferation and differentiation was investigated. The results indicate that nanostructed titanium does enhance osseointegration function and furthermore that the nanotube diameter does affect the proliferation and osteodifferentiation of ADSC.