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Hemocompatibility of hyaluronan enhanced linear low-density polyethylene for heart valve leaflet applications

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dc.contributor.authorSimon-Walker, Rachael, author
dc.contributor.authorPopat, Ketul C., advisor
dc.contributor.authorReynolds, Melissa, committee member
dc.contributor.authorOrton, Christopher, committee member
dc.contributor.authorChicco, Adam, committee member
dc.date.accessioned2019-01-07T17:19:37Z
dc.date.available2019-01-07T17:19:37Z
dc.date.issued2018
dc.description.abstractHeart valve disease is a major concern in both developed countries with advanced ageing populations and undeveloped countries which experience a high incidence of rheumatism leading to valvular disease. To reduce mortality and improve quality of life, heart valve implantations have been widely used to assist in improving function of the native cardiovascular system. While mechanical heart valves and tissue-based heart valves have been successfully used to improve quality of life compared to untreated valvular disease, draw-backs are inherent. Mechanical heart valves are prone to thrombosis and require life-long supplemental anti-coagulation therapy. Tissue-based valves are more hemocompatible, but lack the durability required for long-term implantation. To address these issues, polymeric heart valves have been highly sought after due to polymers' abilities to enhance durability and be manufactured to be similar to the native heart valve leaflet. In addition, their surfaces can be modified to increase hemocompatibility. In this work we explore the hemocompatibility and immune response to a novel polymer for use in heart valve leaflet applications; hyaluronan enhanced linear low-density polyethylene. It is proposed that the combination of linear low-density polyethylene with hyaluronan will create a highly durable material that will reduce thrombosis and inflammation due to the anionic and hydrophilic nature of the glycosaminoglycan.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierSimonWalker_colostate_0053A_15221.pdf
dc.identifier.urihttps://hdl.handle.net/10217/193185
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectheart valves
dc.subjectimmune response
dc.subjectpolymers
dc.subjecthemocompatibility
dc.subjectbiomaterials
dc.subjectplatelets
dc.titleHemocompatibility of hyaluronan enhanced linear low-density polyethylene for heart valve leaflet applications
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBioengineering
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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