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Effect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate

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dc.contributor.authorLonac, Mark Charles, author
dc.contributor.authorBell, Christopher, advisor
dc.contributor.authorHickey, Matthew S., committee member
dc.contributor.authorNelson-Ceschin, Tracy L., committee member
dc.contributor.authorMelby, Christopher L., committee member
dc.date.accessioned2007-01-03T06:12:15Z
dc.date.available2007-01-03T06:12:15Z
dc.date.issued2009
dc.descriptionDepartment Head: Richard Gay Israel.
dc.description.abstractThe sympathetic nervous system (SNS) both provides tonic support of resting metabolic rate (RMR) and mediates approximately one-third of the thermic effect of feeding (TEF), the latter accounting for ~10% of daily energy expenditure. Epigallocatechin-3-gallate (EGCG), the most abundant and bioactive catechin in green tea, inhibits the catecholamine-degrading action of the enzyme catechol-O-methyltransferase, thereby prolonging SNS activation. Accordingly, we hypothesized that short-term EGCG supplementation would augment RMR and TEF in healthy adult humans. METHODS: Sixteen subjects reported to our lab on two mornings (≥ 10 days apart) after 12 hours without food, caffeine, and alcohol and 24 hours without exercise. Each visit followed double-blinded, randomized EGCG or cornmeal placebo supplementation (seven pills over 48 hours, 135 mg EGCG/pill). RMR and respiratory exchange ratio (RER) were determined using the ventilated hood technique for 45 minutes prior to consumption of a liquid mixed-composition meal providing calories equivalent to 40% of RMR. Energy expenditure (EE) and RER were then measured for the first 20 of every 30 minutes for five hours. RESULTS: All subjects (n = 9 males, n =7 females; age 25 ± 2 yrs, mean ± s.e.; 22.6 ± 1.8% body fat) were weight stable and were washed out from prior green tea or EGCG use for ≥ one month. Results are reported as placebo vs. EGCG. EGCG did not affect RMR or baseline RER (RMR: 1665 ± 84 vs. 1610 ± 89 kcal/day; p = 0.10; RER: 0.82 ± 0.01 vs. 0.83 ± 0.01; p = 0.29). EGCG did not affect the area under the TEF response curve, expressed as absolute postprandial EE (441,083 ± 22,436 vs. 429,350 ± 24,209 arbitrary units, A.U.; p = 0.22) or the absolute (58,104 ± 5,297 vs. 58,949 ± 5,672 A.U.; p = 0.88) or percentage (3,508 ± 263 vs. 3,647 ± 285 A.U.; p = 0.67) difference between absolute postprandial EE and baseline RMR. No differences between placebo and EGCG were observed for RER during TEF. CONCLUSION: These results indicate that, contrary to our hypothesis, short-term EGCG supplementation does not influence RMR or TEF in healthy adults. This suggests that reported positive benefits of green tea on energy balance are the result of increased physical activity EE and/or decreased energy intake.
dc.format.mediummasters theses
dc.identifier2009_fall_Lonac_HAES.pdf
dc.identifierETDF2009100006HAES
dc.identifier.urihttp://hdl.handle.net/10217/34983
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relationCatalog record number (MMS ID): 991012226489703361
dc.relationQP176.L653 2009
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.titleEffect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineHealth and Exercise Science
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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