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Novel modulators of blood pressure with age: a physiological and bioinformatics-based approach

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dc.contributor.authorBachman, Nate P., author
dc.contributor.authorBraun, Barry, advisor
dc.contributor.authorLaRocca, Thomas J., advisor
dc.contributor.authorChicco, Adam J., committee member
dc.contributor.authorGentile, Christopher L., committee member
dc.date.accessioned2022-01-07T11:30:43Z
dc.date.available2024-01-06T11:30:43Z
dc.date.issued2021
dc.description.abstractSystolic blood pressure (SBP) increases with age and is a significant risk factor cardio- and cerebrovascular diseases. While the causes of high blood pressure (hypertension) have been extensively studied, the causes of the age-related rise in blood pressure independent of chronic disease remain unclear. Thus, the identification of novel mechanisms underlying age-related high blood pressure may lead to new strategies to reduce chronic disease risk in older adults. Therefore, the goal of this dissertation was to use both physiological and bioinformatics-based approaches to better elucidate contributors to elevated blood pressure in healthy older adults. The main findings are that 1) inhibition of Rho-kinase (an enzyme that participates in numerous cellular/regulatory pathways) lowers systemic blood pressure in healthy older adults concomitant with reduced vascular resistance but not improved endothelial function, 2) genes expression patterns in peripheral white blood cells differ in healthy older adults with elevated SBP compared to those with normal SBP and transcriptomic (RNA) changes relate to vascular and immune function, and 3) circulating chemokines and whole blood immune-related transcripts track with elevated SBP in healthy older adults. Taken together, this work shows that Rho-kinase, circulating RNA transcripts, and circulating chemokines may be novel therapeutic targets and/or biomarkers of elevated blood pressure in healthy older adults with untreated hypertension.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierBachman_colostate_0053A_16899.pdf
dc.identifier.urihttps://hdl.handle.net/10217/234285
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectblood pressure
dc.subjectinflammation
dc.subjecttranscriptomics
dc.subjecthypertension
dc.subjectaging
dc.subjectRho-kinase
dc.titleNovel modulators of blood pressure with age: a physiological and bioinformatics-based approach
dc.typeText
dcterms.embargo.expires2024-01-06
dcterms.embargo.terms2024-01-06
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineHealth and Exercise Science
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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