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Effects of copper source and concentration on copper status and immune function in growing and finishing steers

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dc.contributor.authorDorton, Kristy L., author
dc.contributor.authorEngle, Terry E., advisor
dc.contributor.authorHamar, Dwayne W., committee member
dc.contributor.authorSiciliano, Paul D., committee member
dc.date.accessioned2016-03-15T20:16:06Z
dc.date.available2016-03-15T20:16:06Z
dc.date.issued2002
dc.description.abstractForty-eight, individually fed, purebred Angus steers (approximately 7 months of age, 218 + 9.1 kg) were used to determine the effects of copper (Cu) source and concentration on performance, Cu status, and immune function. Steers were stratified by weight and initial liver Cu concentration and randomly assigned to one of five treatments. Treatments consisted of: 1) control (no supplemental Cu), 2) 10 mg Cu/kg DM from Cu sulfate (CuS04), 3) 10 mg Cu/kg DM from a Cu-amino acid complex (Availa Cu), 4) 20 mg Cu/kg DM from CuS04, and 5) 20 mg Cu/kg DM from Availa Cu. Steers were housed in individual pens and fed an alfalfa-com based growing diet for 56 d then were fed a high concentrate diet for 144 d. On d 56 of the growing phase and d 112 of the finishing phase, liver Cu concentrations were higher (P < 0.01) in Cu supplemented steers. Steers receiving 20 mg Cu/kg DM had higher (P < 0.01) liver Cu concentrations than steers receiving 10 mg Cu/kg DM. On d 112 of the finishing phase, steers receiving 20 mg Cu/kg DM from Availa Cu had higher (P < 0.01) liver copper concentrations than steers supplemented 20 mg Cu/kg DM from CuS04. In the growing phase, steers supplemented with 20 mg Cu/kg DM had greater (P < 0.04) plasma Cu concentrations than steers supplemented with 10 mg Cu/kg DM. In the growing and finishing phases, plasma Cu concentrations were higher (P < 0.03) in steers supplemented with 20 mg Cu/kg DM from Availa Cu than steers receiving 20 mg Cu/kg DM from CuS04. Cell mediated immune response to phytohemagglutinin was higher (P < 0.01) in steers supplemented with 20 mg Cu/kg DM than 10 mg Cu/kg DM treatments. Total immunoglobulin (lg) and immunoglobulin G (IgG) concentrations specific to pig red blood cells (PRBC) were greater (P < 0.01) in steers supplemented with 10 mg Cu/kg DM from CuS04 than 10 mg Cu/kg DM from Availa Cu. During the finishing phase, IgG concentrations specific to PRBC were higher (P < 0.03) and antibody titers specific to ovalbumin (OVA) were lower (P < 0.05) in control steers relative to Cu supplemented steers. Steers receiving 20 mg Cu/kg DM had higher antibody titers specific to OVA (P < 0.02) than 10 mg Cu/kg DM steers. Steers receiving 20 mg Cu/kg DM from Availa Cu had higher (P < 0.01) antibody titers specific to OVA than steers supplemented with 20 mg Cu/kg DM from CuS04 . These results indicate that Cu source and concentration may have an effect on the immune system. Furthermore, it appears that the immune response to an antigen varies depending on the type of antigen administered as well as the concentration and source of Cu supplemented.
dc.format.mediummasters theses
dc.identifier.urihttp://hdl.handle.net/10217/171091
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relationCatalog record number (MMS ID): 991015598649703361
dc.relationSF207.D67 2002
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectBeef cattle
dc.subjectCopper in animal nutrition
dc.titleEffects of copper source and concentration on copper status and immune function in growing and finishing steers
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineAnimal Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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