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Significance of ERα, HER2, and CAV1 expression and molecular subtype classification to canine mammary gland tumor

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dc.contributor.authorShinoda, Hitomi, author
dc.contributor.authorHanneman, William H., advisor
dc.contributor.authorLegare, Marie E., committee member
dc.contributor.authorMason, Gary L., committee member
dc.date.accessioned2007-01-03T05:33:53Z
dc.date.available2014-06-30T04:54:32Z
dc.date.issued2013
dc.description.abstractCanine mammary gland tumor and human breast cancer share many similar features regarding their risk factors, histopathological features, and behavior. Despite the increasing evidence of molecular marker expression as a prognostic factor for human breast cancer, there are only little studies using this approach on canine mammary gland tumor. Our aim was to evaluate the significance of the expression of Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 to the behavior and the clinical outcome of canine mammary gland tumor by Immunohistochemistry. We also assessed the correlation between 5 subtype classification (Luminal A, Luminal B, HER2-overexpressing, Basal-like, and Normal-like) and tumor behavior and prognosis. Canine mammary gland tissues were stained for Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 and evaluated for the positivity, and classified into 5 subtypes according to the staining status. Although there was no statistical significance among the subtypes, the positivity of Nuclear Estrogen Receptor-alpha, Extranuclear Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 showed significant correlations (p<0.05) in the behavior and the prognosis of the tumor. This study indicates the prognostic value of immunohistochemistry staining status of Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 for canine mammary gland tumor. In addition, some trends were seen in 5 subtypes on the prognosis of the tumor, implying that although further analysis is needed, the potential application of 5 subtype classification to canine mammary gland tumor.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierShinoda_colostate_0053N_11723.pdf
dc.identifier.urihttp://hdl.handle.net/10217/79165
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectmolecular subtypes
dc.subjectestrogen receptor alpha
dc.subjecthuman epidermal growth factor receptor 2
dc.subjecthuman breast cancer
dc.subjectcanine mammary gland tumor
dc.subjectCaveolin 1
dc.titleSignificance of ERα, HER2, and CAV1 expression and molecular subtype classification to canine mammary gland tumor
dc.typeText
dcterms.embargo.expires2014-06-30
dcterms.embargo.terms2014-06-30
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineEnvironmental and Radiological Health Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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