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Cognitive effects of exposure to manganese in drinking water in California school children

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dc.contributor.authorMurphy, Eryn, author
dc.contributor.authorReif, John S., advisor
dc.contributor.authorTjalkens, Ronald B., committee member
dc.contributor.authorChen, Peter, committee member
dc.date.accessioned2007-01-03T04:55:24Z
dc.date.available2007-01-03T04:55:24Z
dc.date.issued2010
dc.description.abstractThe hypothesis tested in this study was that low level exposure to manganese in children through drinking water is associated with impaired cognitive performance on standardized tests of intellectual function. The study was based on the pathological and toxicological effects of exposure to manganese in laboratory animals and recent epidemiologic evidence showing an association between exposures to manganese in drinking water and decreased intellectual function (IQ) as well as hyperactive behaviors in children. A clear analogy with lead exists. California has a statewide monitoring system for drinking water manganese which was used to identify school districts for water sampling and analysis. Target school districts were identified for sampling from the California Department of Public Health Drinking Water Program. 100 schools within those cities were identified with manganese concentrations ranging from 20 µg /L to over 900 µg /L. Water samples were collected (n=81), analyzed for manganese concentration (ppb), and grouped into three exposure categories High (>30µg/L), Low (2 -29µg/L), and ND (<2µg/L). Cognitive assessment was determined from standardized test score data for 3rd, 4th, and 5th grade children from the California Standardized Testing and Reporting Program (STAR) for each school. Analysis of Variance, Analysis of Covariance, and Mixed Effect General Linear Regression analyses were used to analyze the data and adjusted for covariates including age, gender, ethnicity, parental education and economic status. The results of this study did not suggest mean test scores to be significantly different between high, low, and non-detect manganese exposure groups when adjusted for confounders. Mean test scores were not highest in the non-detect exposure group and lowest in the high exposure group as predicted.
dc.format.mediummasters theses
dc.identifier2010_Fall_Murphy_Eryn.pdf
dc.identifierETDF2010300050ERHS
dc.identifier.urihttp://hdl.handle.net/10217/46000
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectmanganese
dc.subjectchildren
dc.subjectdrinking water
dc.subjectcognition
dc.subjectManganese -- Physiological effect -- California
dc.subjectChildren -- Intelligence levels -- California
dc.subjectDrinking water -- Contamination -- California
dc.titleCognitive effects of exposure to manganese in drinking water in California school children
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineEnvironmental and Radiological Health Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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